Using a Nonlymphoablative Irradiation-Free Mixed Chimerism and Allograft Tolerance Roles of Deletion and Regulation in Creating
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Allogenic mixed chimerism prevented autoimmune thrombocytopenia in BXSB lupus mice receiving donor BMT with nonlymphoablative conditioning of low-dose TBI and anti-CD40L mAb
Objectives: We have demonstrated that allogeneic bone marrow transplant (BMT) with low-dose total body irradiation (TBI) and anti-CD40L mAb without lymphoablative treatment achieved durable mixed chimerism and permanent donor-specific tolerance. Also, allogeneic mixed chimerism induced by anti-CD40L-containing regimen overcomes both alloand autoimmunity in NOD mice. BXSB mice with a lymphoproli...
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The induction of donor-specific transplant tolerance has always been a central problem for small bowel transplantation (SBT), which is thought to be the best therapy for end-stage bowel failure. With the development of new tolerance-inducing strategies, mixed chimerism induced by co-stimulation blockade has become most potent for tolerance of allografts, such as skin, kidney, and heart. However...
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Transplantation tolerance, defined as allograft acceptance by an immunocompetent recipient in the absence of long-term immunosuppression, has remained an elusive goal in clinical transplantation. Robust experimental tolerance induction strategies have in common methods to induce mixed hemopoietic chimerism. To date, however, chimerism induction across allogeneic barriers has required recipient ...
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Immune tolerance to organ transplants has been reported in laboratory animals and in humans after nonmyeloablative conditioning of the host and infusion of donor bone marrow cells. We examined the mechanisms of immune tolerance to mouse cardiac allografts in MHC-mismatched hosts that developed mixed chimerism after posttransplant conditioning with a 2-wk course of multiple doses of lymphoid tis...
متن کاملAlloreactive Regulatory T Cells Allow the Generation of Mixed Chimerism and Transplant Tolerance
The induction of donor-specific transplant tolerance is one of the main goals of modern immunology. Establishment of a mixed chimerism state in the transplant recipient has proven to be a suitable strategy for the induction of long-term allograft tolerance; however, current experimental recipient preconditioning protocols have many side effects, and are not feasible for use in future therapies....
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تاریخ انتشار 2005